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Ordinary Reweighting | Solactive United States Biotechnology Index | Effective Date 20th March 2023

In the ordinary reweighting, the following index composition will be implemented effective open 20.03.2023:

10X GENOMICS INC
22ND CENTURY GROUP INC
23ANDME HOLDING CO
2SEVENTY BIO INC-W/I
4D MOLECULAR THERAPEUTICS INC
89BIO INC
AADI BIOSCIENCES INC
ABCAM PLC
ABCELLERA BIOLOGICS INC
ACADIA PHARMACEUTICALS INC
ACLARIS THERAPEUTICS INC
ACRIVON THERAPEUTICS INC
ACUMEN PHARMACEUTICALS INC
ADAPTIVE BIOTECHNOLOGIES CORP
ADICET BIO INC
ADMA BIOLOGICS INC
AEROVATE THERAPEUTICS INC
AFFIMED NV
AGENUS INC
AGIOS PHARMACEUTICALS INC
AKERO THERAPEUTICS INC
Akoya Biosciences Inc
ALDEYRA THERAPEUTICS INC
ALECTOR INC
ALKERMES PLC
ALLAKOS INC
ALLOGENE THERAPEUTICS INC
ALLOVIR INC
ALNYLAM PHARMACEUTICALS INC
ALTIMMUNE INC
AMARIN CORPORATION PLC -ADR
AMGEN INC
AMICUS THERAPEUTICS INC
AMPHASTAR PHARMACEUTICALS INC
AMYLYX PHARMACEUTICALS INC
ANAPTYSBIO INC
ANAVEX LIFE SCIENCES CORP
ANI PHARMACEUTICALS INC
APELLIS PHARMACEUTICALS INC
ARBUTUS BIOPHARMA CORP
ARCELLX INC
ARCTURUS THERAPEUTICS HOLDINGS INC
ARCUTIS BIOTHERAPEUTICS INC
ARDELYX INC
ARGENX SE – ADR
ARROWHEAD PHARMACEUTICALS INC
ARS Pharmaceuticals Inc
ARVINAS INC
ASCENDIS PHARMA A/S
ASTRAZENECA PLC-SPONS ADR
ATAI LIFE SCIENCES B.V
ATARA BIOTHERAPEUTICS INC
ATEA PHARMACEUTICALS INC
AURA BIOSCIENCES INC
AURINIA PHARMACEUTICALS INC
AVADEL PHARMACEUTICALS PLC
AVID BIOSERVICES INC
AVIDITY BIOSCIENCES INC
AXSOME THERAPEUTICS INC
BEAM THERAPEUTICS INC
BEIGENE LTD-ADR
BELLUS HEALTH INC
BICYCLE THERAPEUTICS LTD-ADR
BIO-TECHNE CORP
BIOATLA INC
BIOCRYST PHARMACEUTICALS INC
BIOGEN INC
BIOMARIN PHARMACEUTICAL INC
BIONANO GENOMICS INC
BIONTECH SE
BIOVIE INC
BIOXCEL THERAPEUTICS INC
BLUEBIRD BIO INC
BLUEPRINT MEDICINES CORP
BRIDGEBIO PHARMA INC
C4 THERAPEUTICS INC
CARA THERAPEUTICS INC
CARIBOU BIOSCIENCES INC
CASSAVA SCIENCES INC
CATALYST PHARMACEUTICALS INC
CENTURY THERAPEUTICS INC
CEREVEL THERAPEUTICS HOLDINGS INC
CHINOOK THERAPEUTICS INC
COGENT BIOSCIENCES INC
COHERUS BIOSCIENCES INC
COLLEGIUM PHARMACEUTICAL INC
COMPASS PATHWAYS PLC
CORCEPT THERAPEUTICS INC
CRINETICS PHARMACEUTICALS INC
CRISPR THERAPEUTICS AG
CTI BIOPHARMA CORP
CULLINAN ONCOLOGY INC
CUREVAC BV
CYMABAY THERAPEUTICS INC
CYTOKINETICS INC
DAY ONE BIOPHARMACEUTICALS I
DECIPHERA PHARMACEUTICALS INC
DENALI THERAPEUTICS INC
DESIGN THERAPEUTICS INC
DICE MOLECULES HOLDINGS ORD
DYNAVAX TECHNOLOGIES CORP
DYNE THERAPEUTICS INC
EAGLE PHARMACEUTICALS INC/DE
EDGEWISE THERAPEUTICS INC
EDITAS MEDICINE INC
EIGER BIOPHARMACEUTICALS INC
ENANTA PHARMACEUTICALS INC
ENTRADA THERAPEUTICS INC
EQRX INC
ERASCA INC
ESPERION THERAPEUTICS INC
EVOLUS INC
EXELIXIS INC
FATE THERAPEUTICS INC
FENNEC PHARMACEUTICALS INC
FIBROGEN INC
FOGHORN THERAPEUTICS INC.
FULCRUM THERAPEUTICS INC
G1 THERAPEUTICS INC
GALAPAGOS NV SPONSORED ADR
GENERATION BIO CO
GENMAB A/S
GERON CORP
GILEAD SCIENCES INC
GOSSAMER BIO INC
GRAPHITE BIO INC
GRIFOLS SA-ADR
GRITSTONE BIO INC
HALOZYME THERAPEUTICS INC
HARMONY BIOSCIENCES HOLDINGS INC
HARROW HEALTH INC
HERON THERAPEUTICS INC
HESKA CORP
HILLEVAX INC
HORIZON THERAPEUTICS PLC
HUMACYTE INC
HUTCHISON CHINA MEDITECH-ADR
I-MAB
IDEAYA BIOSCIENCES INC
IGM BIOSCIENCES INC
ILLUMINA INC
IMMATICS N.V.
IMMUNITYBIO INC
IMMUNOCORE HOLDINGS PLC
IMMUNOGEN INC
IMMUNOVANT INC
INCYTE CORP
INHIBRX INC
INNOVIVA INC
INOVIO PHARMACEUTICALS INC
INSMED INC
INTELLIA THERAPEUTICS INC
INTERCEPT PHARMACEUTICALS INC
INTRA-CELLULAR THERAPIES INC
INVIVYD INC
IONIS PHARMACEUTICALS INC
IOVANCE BIOTHERAPEUTICS INC
IRONWOOD PHARMACEUTICALS INC
Iteos Therapeutics Inc
IVERIC BIO INC
JANUX THERAPEUTICS INC
JAZZ PHARMACEUTICALS PLC
KARUNA THERAPEUTICS INC
KARYOPHARM THERAPEUTICS INC
KEROS THERAPEUTICS INC
KEZAR LIFE SCIENCES INC
KINIKSA PHARMACEUTICALS-A
Kinnate Biopharma Inc
KODIAK SCIENCES INC
KRYSTAL BIOTECH INC
KURA ONCOLOGY INC
KYMERA THERAPEUTICS INC
LEGEND BIOTECH CORP
LEXICON PHARMACEUTICALS INC
LIGAND PHARMACEUTICALS INC
LIQUIDIA TECHNOLOGIES INC
LYELL IMMUNOPHARMA INC
MACROGENICS INC
MADRIGAL PHARMACEUTICALS INC
MANNKIND CORP
MARINUS PHARMACEUTICALS INC
MaxCyte Inc
MEIRAGTX HOLDINGS PLC
MERSANA THERAPEUTICS INC
MERUS BV
MIRATI THERAPEUTICS INC
MIRUM PHARMACEUTICALS INC
MODERNA INC
MONTE ROSA THERAPEUTICS INC
MORPHIC HOLDING INC
NANOSTRING TECHNOLOGIES INC
NEKTAR THERAPEUTICS
NEUROCRINE BIOSCIENCES INC
NEWAMSTERDAM PHARMA CO NV
NGM BIOPHARMACEUTICALS INC
NKARTA INC
NOVAVAX INC
NURIX THERAPEUTICS INC
Nuvalent Inc
OCUGEN INC
OCULAR THERAPEUTIX INC
OLINK HOLDING AB – ADR
ORAMED PHARMACEUTICALS INC
PACIRA BIOSCIENCES INC
PDS BIOTECHNOLOGY CORP
PEPGEN INC
PETIQ INC
PHATHOM PHARMACEUTICALS INC
PHIBRO ANIMAL HEALTH CORP
PLIANT THERAPEUTICS INC
POINT BIOPHARMA GLOBAL INC
POSEIDA THERAPEUTICS INC
PRECIGEN INC
PRIME MEDICINE INC
PROKIDNEY CORP
PROMETHEUS BIOSCIENCES INC
PROTAGONIST THERAPEUTICS INC
PROTHENA CORP PLC
PROVENTION BIO INC
PTC THERAPEUTICS INC
PUMA BIOTECHNOLOGY INC
RAPT THERAPEUTICS INC
REATA PHARMACEUTICALS INC-A
REGENERON PHARMACEUTICALS
REGENXBIO INC
RELAY THERAPEUTICS INC
REPARE THERAPEUTICS INC
REPLIGEN CORP
REPLIMUNE GROUP INC
REVANCE THERAPEUTICS INC
REVOLUTION MEDICINES INC
RHYTHM PHARMACEUTICALS INC
ROCKET PHARMACEUTICALS INC
ROIVANT SCIENCES LTD
ROYALTY PHARMA PLC- CL A
RXRX.OQ
SAGE THERAPEUTICS INC
SANA BIOTECHNOLOGY INC
SANGAMO THERAPEUTICS INC
SANOFI-ADR
SAREPTA THERAPEUTICS INC
SCHOLAR ROCK HOLDING CORP
SCPHARMACEUTICALS INC
SEAGEN INC
SEER INC
SELECTA BIOSCIENCES INC
SERES THERAPEUTICS INC
SIGA TECHNOLOGIES INC
SPRINGWORKS THERAPEUTICS INC
STOKE THERAPEUTICS INC
SUPERNUS PHARMACEUTICALS INC
SUTRO BIOPHARMA INC
SYNDAX PHARMACEUTICALS INC
TANGO THERAPEUTICS INC
TARSUS PHARMACEUTICALS INC
TERNS PHARMACEUTICALS INC
TG THERAPEUTICS INC
THERAVANCE BIOPHARMA INC
THIRD HARMONIC BIO INC
TRAVERE THERAPEUTICS INC
TWIST BIOSCIENCE CORP
ULTRAGENYX PHARMACEUTICAL INC
UNIQURE B.V.
UNITED THERAPEUTICS CORP
VANDA PHARMACEUTICALS INC
VAXCYTE INC
VENTYX BIOSCIENCES INC
VERA THERAPEUTICS INC
VERONA PHARMA PLC – ADR
VERTEX PHARMACEUTICALS INC
VERU INC
VERVE THERAPEUTICS INC
VIATRIS INC
VIKING THERAPEUTICS INC
VIR BIOTECHNOLOGY INC
VIRIDIAN THERAPEUTICS INC
WAVE LIFE SCIENCES PTE LTD
XENCOR INC
XENON PHARMACEUTICALS INC
XERIS BIOPHARMA HOLDINGS INC
ZAI LAB LTD
ZENTALIS PHARMACEUTICALS INC
ZYMEWORKS INC