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Ordinary Re-Weighting | RBC Biotech Opportunities GTR Index | Effective Date 2nd January 2024

RBC Biotech Opportunities GTR Index:

In the ordinary re-weighting, the following composition will be implemented effective open 2nd January 2024:

ABBVIE INC
ALNYLAM PHARMACEUTICALS INC
BIOGEN INC
BIOMARIN PHARMACEUTICAL INC
GILEAD SCIENCES INC
INCYTE CORP
INTRA-CELLULAR THERAPIES INC
KARUNA THERAPEUTICS INC
ELI LILLY & CO
SAREPTA THERAPEUTICS INC