Ordinary Index Rebalancing in the Solactive Pharma Breakthrough Value Index | September 2019

In the ordinary rebalance the following composition will be implemented:

ALEXION PHARMACEUTICALS INC
BEIGENE LTD-ADR
BIOGEN INC
BIOMARIN PHARMACEUTICAL INC
CELGENE CORP
CSL LTD ORD
EMERGENT BIOSOLUTIONS INC
GRIFOLS SA CLASS A
H LUNDBECK AS
HALOZYME THERAPEUTICS INC
HORIZON THERAPEUTICS PLC
INCYTE CORP
IONIS PHARMACEUTICALS INC
IPSEN SA
JAZZ PHARMACEUTICALS PLC
LIGAND PHARMACEUTICALS INC
MALLINCKRODT PLC
NIPPON SHINYAKU CO LTD
NOVARTIS AG
PTC THERAPEUTICS INC
REGENERON PHARMACEUTICALS
RETROPHIN INC
SANTEN PHARMACEUTICAL CO LTD ORD
SWEDISH ORPHAN BIOVITRUM AB
TAKEDA PHARMACEUTICAL
ULTRAGENYX PHARMACEUTICAL INC
UNITED THERAPEUTICS CORP
VERTEX PHARMACEUTICALS INC