Ordinary Adjustment | Solactive Pharma Breakthrough Value Index | March 2019

In the ordinary rebalancing the following composition will be implemented:

BUKWANG PHARMACEUTICAL CO
TAKEDA PHARMACEUTICAL
NIPPON SHINYAKU CO LTD
EISAI
AGIOS PHARMACEUTICALS INC
ALEXION PHARMACEUTICALS INC
ARRAY BIOPHARMA INC
BEIGENE LTD-ADR
BIOGEN INC
BIOMARIN PHARMACEUTICAL INC
BASILEA PHARMACEUTICA LTD.
BTG PLC
CELGENE CORP
CSL LTD ORD
EMERGENT BIOSOLUTIONS INC
GRIFOLS SA CLASS A
HORIZON PHARMA PLC
INCYTE CORP
IONIS PHARMACEUTICALS INC
IPSEN SA
JAZZ PHARMACEUTICALS PLC
LIGAND PHARMACEUTICALS INC
MALLINCKRODT PLC
NOVARTIS AG
PHARMA MAR SA
PTC THERAPEUTICS INC
ULTRAGENYX PHARMACEUTICAL INC
RETROPHIN INC
SWEDISH ORPHAN BIOVITRUM AB
SPECTRUM PHARMACEUTICALS INC
UNITED THERAPEUTICS CORP
VERTEX PHARMACEUTICALS INC