Change of Listing | SPRUCE BIOSCIENCES INC | 2nd May 2025

On April 22, 2025, SPRUCE BIOSCIENCES INC received a written notification from Nasdaq that as a result of the Company’s ongoing failure to comply with the Minimum Bid Price Requirement, SPRUCE BIOSCIENCES INC common stock has been delisted from Nasdaq at the open of trading on April 29, 2025. SPRUCE BIOSCIENCES INC shares will be quoted OTC beginning April 29. 2025.

The treatment below will be applied to the following indices:

• SPRUCE BIOSCIENCES INC will be removed from the Index.
• The weight of SPRUCE BIOSCIENCES INC (SPRB.PK) based on its last close price will be distributed pro rata to remaining Index constituents.
• Effective Date (open): 02/05/2025

Solactive US Extended Broad Market Index (GTR)