Acquisition | REGULUS THERAPEUTICS INC | 25th June 2025

Initially announced on April 30, 2025, NOVARTIS AG made a cash offer for REGULUS THERAPEUTICS INC of USD 7 plus one contingent value right per REGULUS THERAPEUTICS INC share held. The tender offer closes on June 25, 2025. Due to the presence of a contingent value right in the offer, REGULUS THERAPEUTICS INC will be removed at its last close price effective (open) June 25, 2025.

The treatment below will be applied to the following indices:

• REGULUS THERAPEUTICS INC will be removed from the Index.
• The weight of REGULUS THERAPEUTICS INC (RGLS.OQ) based on its last close price will be distributed pro rata to remaining Index constituents.
• Effective Date (open): 25/06/2025

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