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Ordinary Re-Weighting | RBC Biotech Opportunities Index | Effective Date 1st April 2025

RBC Biotech Opportunities Index:

In the ordinary re-weighting, the following composition will be implemented effective open 1st April 2025:

ABBVIE INC
ALNYLAM PHARMACEUTICALS INC
BIOGEN INC
BIOMARIN PHARMACEUTICAL INC
ELI LILLY & CO
GILEAD SCIENCES INC
INCYTE CORP
INTRA-CELLULAR THERAPIES INC
SAREPTA THERAPEUTICS INC