Ordinary Adjustment | Solactive Pharma & Biotech Opportunity Index | August 2018

In the ordinary rebalance the following composition will be implemented:

YUHAN CORP ORD
CHINA TRADITIONAL CHINESE MEDICINE HOLDINGS CO LTD
CHINA MEDICAL SYSTEM HOLDINGS LTD
SINOPHARM GROUP CO LTD
3SBIO INC
LUYE PHARMA GROUP LTD
ONO PHARMACEUTICAL CO LTD ORD
SANTEN PHARMACEUTICAL CO LTD ORD
SAWAI PHARMACEUTICAL CO LTD ORD
AKORN INC
ALKERMES PLC
ALNYLAM PHARMACEUTICALS INC
ASPEN PHARMACARE HOLDINGS LT
BLUEBIRD BIO INC
BTG PLC
CAMBREX CORP
CHINA BIOLOGIC PRODUCTS HOLD
CHARLES RIVER LABORATORIES
GALAPAGOS NV
HIKMA PHARMACEUTICALS PLC
HORIZON PHARMA PLC
JAZZ PHARMACEUTICALS PLC
MEDPACE HOLDINGS INC
MERCK KGAA
MYLAN NV
OPKO HEALTH INC
REPLIGEN CORP
SYNEOS HEALTH INC
UCB SA
XENCOR INC