Acquisition | AVIDITY BIOSCIENCES INC | 2nd March 2026

Initially announced on October 26, 2025 NOVARTIS AG made a cash offer for AVIDITY BIOSCIENCES INC of USD 72 per AVIDITY BIOSCIENCES INC share held. The completion of the event is pending the approval of AVIDITY BIOSCIENCES INC shareholders on February 26, 2026 and the completion of the ATRIUM THERAPEUTICS INC Spin Off on February 27, 2026, which is one of the conditions to the closing of the merger. The Merger is expected to be effective on March 2, 2026. In the absence of an active market, the last close price will reflect the Deal Terms of the transaction. To facilitate the Distribution and transition of the stock symbol in connection with the closing of the Merger, AVIDITY BIOSCIENCES INC common stock will temporarily trade on the Nasdaq Global Market under the symbol RNAM beginning on the date of the Distribution and ATRIUM THERAPEUTICS will trade under the symbol RNA. In case there are any final changes to the scheme timeline during the Special Shareholder Meeting on February 26, Solactive will communicate the updated treatment accordingly.

The treatment below will be applied to the following indices:

• AVIDITY BIOSCIENCES INC will be removed from the Index.
• The weight of AVIDITY BIOSCIENCES INC (RNA.OQ) based on its last close price will be distributed pro rata to remaining Index constituents.
• Effective Date (open): 02/03/2026

RAFI Fundamental Global All Company Index NTR
RAFI Fundamental Global All Company Index PR
RAFI Fundamental Global All Company Index GTR
RAFI Fundamental Select US 1500 NTR Index
RAFI Fundamental Select US 1500 PR Index
RAFI Fundamental Select US 1500 TR Index
Solactive GBS Developed Markets ex Australia Investable Universe USD Index NTR
Solactive GBS Developed Markets ex Australia Investable Universe USD Index PR
Solactive GBS Developed Markets ex Australia Investable Universe USD Index TR
Solactive GBS Global Markets ex Australia Investable Universe USD Index NTR
Solactive GBS Global Markets ex Australia Investable Universe USD Index PR
Solactive GBS Global Markets ex Australia Investable Universe USD Index TR
Solactive ISS CTB-Derived Universe Global Markets All Cap Index NTR
Solactive ISS CTB-Derived Universe Global Markets All Cap Index PR
Solactive ISS CTB-Derived Universe Global Markets All Cap Index TR
Solactive GBS CW DM US & Europe EUR Index NTR
Solactive GBS CW DM US & Europe EUR Index PR
Solactive GBS CW DM US & Europe EUR Index TR
Solactive ISS SDG Aligned Global Markets All Cap Index NTR
Solactive ISS SDG Aligned Global Markets All Cap Index PR
Solactive ISS SDG Aligned Global Markets All Cap Index TR
Solactive Developed Markets Healthcare 150 CAD Index (CA NTR)
Solactive Developed Markets Healthcare 150 CAD Index NTR
Solactive Developed Markets Healthcare 150 CAD Index PR
Solactive Developed Markets Healthcare 150 CAD Index TR
Solactive GBS Developed Markets All Cap USD Index NTR
Solactive GBS Developed Markets All Cap USD Index PR
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Solactive Developed Markets Broad Healthcare EUR Index NTR
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Solactive Developed Markets Healthcare 150 Index NTR
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Solactive Developed Markets Healthcare Mid & Small Cap Index NTR
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Solactive GBS Developed Markets Investable Universe EUR Index NTR
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Solactive GBS Developed Markets Investable Universe EUR Index TR
Solactive GBS Developed Markets Investable Universe USD Index NTR
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Solactive GBS Developed Markets Investable Universe USD Index TR
Solactive GBS Developed Markets Mid & Small Cap EUR Index NTR
Solactive GBS Developed Markets Mid & Small Cap EUR Index PR
Solactive GBS Developed Markets Mid & Small Cap EUR Index TR
Solactive GBS Developed Markets Mid & Small Cap USD Index NTR
Solactive GBS Developed Markets Mid & Small Cap USD Index PR
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Solactive GBS Developed Markets Small Cap AUD Index NTR
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Solactive GBS Developed Markets Small Cap GBP Index NTR
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Solactive GBS Developed Markets Small Cap CAD Index NTR
Solactive GBS Developed Markets Small Cap CAD Index PR
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Solactive GBS Developed Markets Small Cap EUR Index 5% AR
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Solactive GBS Developed Markets Small Cap CHF Index NTR
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Solactive GBS Developed Markets Small Cap SEK Index 5% AR
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Solactive GBS Developed Markets Small Cap USD Index NTR
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Solactive ISS ESG Screened Developed Markets Small Cap Index NTR
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Solactive ISS ESG Screened USA Small Cap Derived Index NTR
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Solactive ISS ESG Screened USA Small Cap Index NTR
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Solactive GBS Global Markets Americas All Cap USD Index NTR
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Solactive GBS Global Markets Americas Investable Universe EUR Index NTR
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Solactive GBS Global Markets Americas Investable Universe USD Index NTR
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Solactive GBS Global Markets Americas Small Cap USD Index NTR
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Solactive GBS Global Markets ex China All Cap EUR Index NTR
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Solactive GBS Global Markets ex China All Cap USD Index NTR
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Solactive GBS Global Markets ex China Investable Universe USD Index NTR
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Solactive GBS Global Markets ex China Small Cap EUR Index NTR
Solactive GBS Global Markets ex China Small Cap EUR Index PR
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Solactive GBS Global Markets ex China Small Cap USD Index NTR
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Solactive GBS Global Markets All Cap EUR Index NTR
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Solactive GBS Global Markets All Cap USD Index NTR
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Solactive GBS Global Markets Investable Universe EUR Index NTR
Solactive GBS Global Markets Investable Universe EUR Index PR
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Solactive GBS Global Markets Investable Universe CHF Index NTR
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Solactive GBS Global Markets Investable Universe USD Index NTR
Solactive GBS Global Markets Investable Universe USD Index PR
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Solactive GBS Global Markets Mid & Small Cap USD Index NTR
Solactive GBS Global Markets Mid & Small Cap USD Index PR
Solactive GBS Global Markets Mid & Small Cap USD Index TR
Solactive GBS Global Markets Small Cap USD Index NTR
Solactive GBS Global Markets Small Cap USD Index PR
Solactive GBS Global Markets Small Cap USD Index TR
Solactive GFS United States 800 Growth Style MV EUR Index NTR
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Solactive GFS United States 800 Growth Style MV GBP Index NTR
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Solactive GFS United States 800 Growth Style MV Index NTR
Solactive GFS United States 800 Growth Style MV Index PR
Solactive GFS United States 800 Growth Style MV Index TR
Solactive GFS United States 1000 Growth Style MV EUR Index NTR
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Solactive GFS United States 1000 Growth Style MV GBP Index NTR
Solactive GFS United States 1000 Growth Style MV GBP Index PR
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Solactive GFS United States 1000 Growth Style MV Index NTR
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Solactive GFS United States 1000 Growth Style MV Index TR
Solactive GFS United States 2500 Growth Style MV EUR Index NTR
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Solactive GFS United States 2500 Growth Style MV GBP Index PR
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Solactive GFS United States 2500 Growth Style MV Index NTR
Solactive GFS United States 2500 Growth Style MV Index PR
Solactive GFS United States 2500 Growth Style MV Index TR
Solactive GFS United States 3000 Growth Style MV EUR Index NTR
Solactive GFS United States 3000 Growth Style MV EUR Index PR
Solactive GFS United States 3000 Growth Style MV EUR Index TR
Solactive GFS United States 3000 Growth Style MV GBP Index NTR
Solactive GFS United States 3000 Growth Style MV GBP Index PR
Solactive GFS United States 3000 Growth Style MV GBP Index TR
Solactive GFS United States 3000 Growth Style MV Index NTR
Solactive GFS United States 3000 Growth Style MV Index PR
Solactive GFS United States 3000 Growth Style MV Index TR
Solactive GFS United States 600 Growth Style MV Index NTR
Solactive GFS United States 600 Growth Style MV Index PR
Solactive GFS United States 600 Growth Style MV Index TR
Solactive GFS United States 1500 Growth Style MV Index NTR
Solactive GFS United States 1500 Growth Style MV Index PR
Solactive GFS United States 1500 Growth Style MV Index TR
Solactive GFS United States 400 + 600 Growth Style MV Index NTR
Solactive GFS United States 400 + 600 Growth Style MV Index PR
Solactive GFS United States 400 + 600 Growth Style MV Index TR
Solactive GFS United States 1000 Growth Style Index NTR
Solactive GFS United States 1000 Growth Style Index PR
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Solactive GFS United States 600 Growth Style Index NTR
Solactive GFS United States 600 Growth Style Index PR
Solactive GFS United States 600 Growth Style Index TR
Solactive GFS United States 1500 Growth Style Index NTR
Solactive GFS United States 1500 Growth Style Index PR
Solactive GFS United States 1500 Growth Style Index TR
Solactive GFS United States 400 + 600 Growth Style Index NTR
Solactive GFS United States 400 + 600 Growth Style Index PR
Solactive GFS United States 400 + 600 Growth Style Index TR
Solactive GBS North America All Cap USD Index NTR
Solactive GBS North America All Cap USD Index PR
Solactive GBS North America All Cap USD Index TR
Solactive GBS North America Investable Universe EUR Index NTR
Solactive GBS North America Investable Universe EUR Index PR
Solactive GBS North America Investable Universe EUR Index TR
Solactive GBS North America Investable Universe CHF Index NTR
Solactive GBS North America Investable Universe CHF Index PR
Solactive GBS North America Investable Universe CHF Index TR
Solactive GBS North America Investable Universe USD Index NTR
Solactive GBS North America Investable Universe USD Index PR
Solactive GBS North America Investable Universe USD Index TR
Solactive GBS North America Mid & Small Cap EUR Index NTR
Solactive GBS North America Mid & Small Cap EUR Index PR
Solactive GBS North America Mid & Small Cap EUR Index TR
Solactive GBS North America Mid & Small Cap USD Index NTR
Solactive GBS North America Mid & Small Cap USD Index PR
Solactive GBS North America Mid & Small Cap USD Index TR
Solactive GBS North America Small Cap USD Index NTR
Solactive GBS North America Small Cap USD Index PR
Solactive GBS North America Small Cap USD Index TR
Solactive GBS Developed Markets ex Oceania Investable Universe USD Index NTR
Solactive GBS Developed Markets ex Oceania Investable Universe USD Index PR
Solactive GBS Developed Markets ex Oceania Investable Universe USD Index TR
Solactive GBS Global Markets ex Oceania Investable Universe USD Index NTR
Solactive GBS Global Markets ex Oceania Investable Universe USD Index PR
Solactive GBS Global Markets ex Oceania Investable Universe USD Index TR
Solactive Evaluate Global Pharma Index NTR
Solactive Evaluate Global Pharma Index PR
Solactive Evaluate Global Pharma Index TR
Solactive Biopharma Select Index NTR
Solactive Biopharma Select Index PR
Solactive Biopharma Select Index TR
Solactive Gerd Kommer Multifactor Equity Index NTR
Solactive Gerd Kommer Multifactor Equity Index PR
Solactive Gerd Kommer Multifactor Equity Index TR
Solactive Gerd Kommer Target Sector Neutral Index NTR
Solactive Gerd Kommer Target Sector Neutral Index PR
Solactive Gerd Kommer Target Sector Neutral Index TR
Solactive Genomics Index
Solactive Genomics v2 Index
Solactive Genomics Index (TR) (INTERNAL ONLY)
Solactive Genomics Index (PR) (INTERNAL ONLY)
Solactive UmweltBank Global Investable Universe SDG PAB Index NTR
Solactive UmweltBank Global Investable Universe SDG PAB Index PR
Solactive UmweltBank Global Investable Universe SDG PAB Index TR
Solactive US Biohealthcare Index NTR
Solactive US Biohealthcare Index PR
Solactive US Biohealthcare Index TR
Solactive US Broad Market Index (GTR)
Solactive US Broad Market Index (PR)
Solactive United States Biotechnology Index NTR
Solactive United States Biotechnology Index PR
Solactive United States Biotechnology Index TR
Solactive US Extended Broad Market Index (GTR)
Solactive US Large & Mid Cap Index (GTR)
Solactive US Large & Mid Cap Index (PR)
Solactive US Small & Mid Cap Index (GTR)
Solactive US Small & Mid Cap Index (PR)
Solactive Wolfe Research Long Leg Index NTR
Solactive U.S. Large & Mid Cap Momentum 100 Index TR
Solactive USA Small Cap Derived Index NTR
Solactive USA Small Cap Derived Index PR
Solactive USA Small Cap Derived Index TR
Solactive ISS PAB-Derived Universe Global Markets All Cap Index NTR
Solactive ISS PAB-Derived Universe Global Markets All Cap Index PR
Solactive ISS PAB-Derived Universe Global Markets All Cap Index TR
Solactive ISS ESG Screened Paris Aligned (PAB) Developed Markets Small Cap Index NTR
Solactive ISS ESG Screened Paris Aligned (PAB) Developed Markets Small Cap Index PR
Solactive ISS ESG Screened Paris Aligned (PAB) Developed Markets Small Cap Index TR
Solactive United States 800 GBP Index NTR
Solactive United States 800 GBP Index
Solactive United States 800 GBP Index TR
Solactive United States 800 EUR Index NTR
Solactive United States 800 EUR Index
Solactive United States 800 EUR Index TR
Solactive United States 800 CHF Index NTR
Solactive United States 800 CHF Index
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Solactive United States 800 Index NTR
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Solactive United States 800 Index TR
Solactive United States 2500 GBP Index NTR
Solactive United States 2500 GBP Index
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Solactive United States 2500 EUR Index NTR
Solactive United States 2500 EUR Index
Solactive United States 2500 EUR Index TR
Solactive United States 2500 CHF Index NTR
Solactive United States 2500 CHF Index
Solactive United States 2500 CHF Index TR
Solactive United States 2500 Index NTR
Solactive United States 2500 Index
Solactive United States 2500 Index TR
Solactive United States 1000 GBP Index NTR
Solactive United States 1000 GBP Index
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Solactive United States 1000 EUR Index NTR
Solactive United States 1000 EUR Index
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Solactive United States 1000 CHF Index NTR
Solactive United States 1000 CHF Index
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Solactive United States 1000 Index NTR
Solactive United States 1000 Index
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Solactive United States 3000 GBP Index NTR
Solactive United States 3000 GBP Index
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Solactive United States 3000 EUR Index NTR
Solactive United States 3000 EUR Index
Solactive United States 3000 EUR Index TR
Solactive United States 3000 CHF Index NTR
Solactive United States 3000 CHF Index
Solactive United States 3000 CHF Index TR
Solactive United States 3000 Index NTR
Solactive United States 3000 Index
Solactive United States 3000 Index TR
Solactive GBS United States All Cap Index NTR
Solactive GBS United States All Cap Index PR
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Solactive GBS United States Investable Universe EUR Index NTR
Solactive GBS United States Investable Universe EUR Index PR
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Solactive GBS United States Investable Universe Index NTR
Solactive GBS United States Investable Universe Index PR
Solactive GBS United States Investable Universe Index TR
Solactive GBS United States Mid & Small Cap Index NTR
Solactive GBS United States Mid & Small Cap Index PR
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Solactive GBS United States Small Cap Index NTR
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Solactive GBS United States Small Cap SEK Index 5% AR
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Solactive GBS United States Small Cap SEK Index PR
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Solactive GBS United States Small Cap Index TR
Solactive GBS Developed Markets ex United Kingdom Investable Universe USD Index NTR
Solactive GBS Developed Markets ex United Kingdom Investable Universe USD Index PR
Solactive GBS Developed Markets ex United Kingdom Investable Universe USD Index TR
Solactive GBS Developed Markets ex Europe Investable Universe USD Index NTR
Solactive GBS Developed Markets ex Europe Investable Universe USD Index PR
Solactive GBS Developed Markets ex Europe Investable Universe USD Index TR
Solactive GBS Developed Markets ex Japan All Cap USD Index NTR
Solactive GBS Developed Markets ex Japan All Cap USD Index PR
Solactive GBS Developed Markets ex Japan All Cap USD Index TR
Solactive GBS Developed Markets ex Japan Investable Universe USD Index NTR
Solactive GBS Developed Markets ex Japan Investable Universe USD Index PR
Solactive GBS Developed Markets ex Japan Investable Universe USD Index TR
Solactive GBS Developed Markets ex Japan Small Cap USD Index NTR
Solactive GBS Developed Markets ex Japan Small Cap USD Index PR
Solactive GBS Developed Markets ex Japan Small Cap USD Index TR
Solactive GBS Developed Markets ex Switzerland Investable Universe CHF Index NTR
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Solactive GBS DM ex US Large & Mid Cap US Listings + US 1000 USD Index NTR
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Solactive GBS Developed Markets ex Eurozone All Cap EUR Index NTR
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Solactive GBS Developed Markets ex Eurozone All Cap USD Index NTR
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Solactive GBS Developed Markets ex Eurozone Investable Universe EUR Index NTR
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Solactive GBS Developed Markets ex Eurozone Investable Universe EUR Index TR
Solactive GBS Developed Markets ex Eurozone Investable Universe USD Index NTR
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Solactive GBS Developed Markets ex Eurozone Investable Universe USD Index TR
Solactive GBS Developed Markets ex Eurozone Small Cap EUR Index NTR
Solactive GBS Developed Markets ex Eurozone Small Cap EUR Index PR
Solactive GBS Developed Markets ex Eurozone Small Cap EUR Index TR
Solactive GBS Developed Markets ex Eurozone Small Cap USD Index NTR
Solactive GBS Developed Markets ex Eurozone Small Cap USD Index PR
Solactive GBS Developed Markets ex Eurozone Small Cap USD Index TR
Solactive GBS United States 1000 Index
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Solactive GBS United States 1000 CAD Index (CA NTR)
Solactive GBS United States 1000 CAD Index NTR
Solactive GBS United States 1000 CAD Index TR
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Solactive GBS United States 1500 Index
Solactive GBS United States 1500 AUD Index
Solactive GBS United States 1500 AUD Index NTR
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Solactive GBS United States 1500 GBP Index
Solactive GBS United States 1500 GBP Index NTR
Solactive GBS United States 1500 GBP Index TR
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Solactive GBS United States 1500 EUR Index
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Solactive GBS United States 1500 CHF Index
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Solactive GBS United States 1500 JPY Index
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Solactive GBS United States 1500 NZD Index
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Solactive GBS United States 400 Index
Solactive GBS United States 400 AUD Index
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Solactive GBS United States 400 EUR Index
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Solactive GBS United States 400 CHF Index
Solactive GBS United States 400 CHF Index NTR
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Solactive GBS United States 400 JPY Index
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Solactive GBS United States 400 Index NTR
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Solactive GBS United States 400 NZD Index
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